In his biographies of Benjamin Franklin, Albert Einstein and Steve Jobs, the historian Walter Isaacson has been drawn to his subjects by their uncanny capacity to make connections across disciplines, combining technical expertise with an artist’s eye for beauty, line and grace. In his latest opus, Isaacson chronicles perhaps history’s greatest creative genius: the 15th century Italian artist, scientist and inventor, Leonardo Da Vinci. From The Mona Lisa to The Last Supper, DaVinci's iconic paintings revolutionized how artists observed the world, and in fields as disparate as geology, botany, anatomy and engineering, he made lasting contributions. Walter Isaacson joins Tom on the line from New York City to talk about the nature of genius, and the rewards of insatiable curiosity.